Reaction Details Report a problem with these data
Target
D-amino-acid oxidase
Ligand
BDBM50431077
Substrate
n/a
Meas. Tech.
DAAO Inhibitory Activity Assay
IC50
4.90±n/a nM
Citation
 Hondo, T; Nakanishi, K; Niimi, T; Warizaya, M; Namatame, I; Harada, K Dihydroxy aromatic heterocyclic compound US Patent  US10202399 Publication Date 2/12/2019 
Target
Name:
D-amino-acid oxidase
Synonyms:
D-amino-acid oxidase (DAAO) | DAAO | DAMOX | DAO | OXDA_HUMAN
Type:
Homodimer
Mol. Mass.:
39476.06
Organism:
Homo sapiens (Human)
Description:
P14920
Residue:
347
Sequence:
MRVVVIGAGVIGLSTALCIHERYHSVLQPLDIKVYADRFTPLTTTDVAAGLWQPYLSDPNNPQEADWSQQTFDYLLSHVHSPNAENLGLFLISGYNLFHEAIPDPSWKDTVLGFRKLTPRELDMFPDYGYGWFHTSLILEGKNYLQWLTERLTERGVKFFQRKVESFEEVAREGADVIVNCTGVWAGALQRDPLLQPGRGQIMKVDAPWMKHFILTHDPERGIYNSPYIIPGTQTVTLGGIFQLGNWSELNNIQDHNTIWEGCCRLEPTLKNARIIGERTGFRPVRPQIRLEREQLRTGPSNTEVIHNYGHGGYGLTIHWGCALEAAKLFGRILEEKKLSRMPPSHL
  
Inhibitor
Name:
BDBM50431077
Synonyms:
CHEMBL2338787 | US10202399, Example 48 | US10463663, Example 56 | US11129828, Example 56 | US9212147, 48 | US9290456, 56 | US9931340, Example 56
Type:
Small organic molecule
Emp. Form.:
C12H12N2O2
Mol. Mass.:
216.2359
SMILES:
CC(c1ccccc1)c1cc(O)c(=O)[nH]n1
Structure:
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