Reaction Details Report a problem with these data
Target
Free fatty acid receptor 1
Ligand
BDBM300805
Substrate
n/a
Meas. Tech.
Calcium Flux Assay
EC50
5.00±n/a nM
Citation
 Huang, H; Kuo, G; Player, MR; Yang, S; Zhang, Y Substituted benzothiophenyl derivatives as GPR40 agonists for the treatment of type II diabetes US Patent  US9790198 Publication Date 10/17/2017 
Target
Name:
Free fatty acid receptor 1
Synonyms:
FFAR1 | FFAR1_HUMAN | G-protein Coupled Receptor 40 | GPR40
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
31473.32
Organism:
Homo sapiens (Human)
Description:
O14842
Residue:
300
Sequence:
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
  
Inhibitor
Name:
BDBM300805
Synonyms:
(3S)-3-[4-[[3-[4-[(4-Hydroxy- 1,1-dioxo-thian-4-yl)methoxy]- 2-methyl-phenyl]benzo[b] thiophen-5-yl]methoxy]phenyl] hex-4-ynoic acid | US10131648, Compound 3 | US10195178, Compound 3 | US9790198, Compound 3
Type:
Small organic molecule
Emp. Form.:
C34H34O7S2
Mol. Mass.:
618.76
SMILES:
CC#C[C@@H](CC(O)=O)c1ccc(OCc2ccc3scc(-c4ccc(OCC5(O)CCS(=O)(=O)CC5)cc4C)c3c2)cc1 |r|
Structure:
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