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Target
MAP kinase-activated protein kinase 2
Ligand
BDBM348779
Substrate
n/a
Meas. Tech.
Mass Spectrometry Assay
IC50
<100±n/a nM
Citation
 Alexander, MD; Chuaqui, C; Malona, J; McDonald, JJ; Ni, Y; Niu, D; Petter, RC; Singh, J; Pabba, C MK2 inhibitors and uses thereof US Patent  US9790235 Publication Date 10/17/2017 
Target
Name:
MAP kinase-activated protein kinase 2
Synonyms:
MAP kinase-activated protein kinase 2 (MAPKAPK2) | MAP kinase-activated protein kinase 2 (MK2) | MAP kinase-activated protein kinase 2 (p38/MK2) | MAPK-Activated Protein Kinase 2 (MK2) | MAPK-activated protein kinase 2 | MAPK2_HUMAN | MAPKAP kinase 2 | MAPKAPK-2 | MAPKAPK2 | MK2
Type:
Serine/threonine-protein kinase
Mol. Mass.:
45579.87
Organism:
Homo sapiens (Human)
Description:
P49137
Residue:
400
Sequence:
MLSNSQGQSPPVPFPAPAPPPQPPTPALPHPPAQPPPPPPQQFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVKEEMTSALATMRVDYEQIKIKKIEDASNPLLLKRRKKARALEAAALAH
  
Inhibitor
Name:
BDBM348779
Synonyms:
US9790235, Number I-30
Type:
Small organic molecule
Emp. Form.:
C20H16ClN7O3S
Mol. Mass.:
469.904
SMILES:
NC(=O)c1cnc(Cl)nc1Nc1ccc2c3c4NC[C@@H](CO)NC(=O)c4sc3ccc2n1 |r|
Structure:
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