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Target
MAP kinase-activated protein kinase 2
Ligand
BDBM348794
Substrate
n/a
Meas. Tech.
Mass Spectrometry Assay
IC50
<100±n/a nM
Citation
 Alexander, MD; Chuaqui, C; Malona, J; McDonald, JJ; Ni, Y; Niu, D; Petter, RC; Singh, J; Pabba, C MK2 inhibitors and uses thereof US Patent  US9790235 Publication Date 10/17/2017 
Target
Name:
MAP kinase-activated protein kinase 2
Synonyms:
MAP kinase-activated protein kinase 2 (MAPKAPK2) | MAP kinase-activated protein kinase 2 (MK2) | MAP kinase-activated protein kinase 2 (p38/MK2) | MAPK-Activated Protein Kinase 2 (MK2) | MAPK-activated protein kinase 2 | MAPK2_HUMAN | MAPKAP kinase 2 | MAPKAPK-2 | MAPKAPK2 | MK2
Type:
Serine/threonine-protein kinase
Mol. Mass.:
45579.87
Organism:
Homo sapiens (Human)
Description:
P49137
Residue:
400
Sequence:
MLSNSQGQSPPVPFPAPAPPPQPPTPALPHPPAQPPPPPPQQFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVKEEMTSALATMRVDYEQIKIKKIEDASNPLLLKRRKKARALEAAALAH
  
Inhibitor
Name:
BDBM348794
Synonyms:
US9790235, Number I-45
Type:
Small organic molecule
Emp. Form.:
C22H21FN6O3S
Mol. Mass.:
468.504
SMILES:
COCCOc1cc(F)nc(Nc2ccc3c4c5NC[C@@H](C)NC(=O)c5sc4ccc3n2)n1 |r|
Structure:
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