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Target
MAP kinase-interacting serine/threonine-protein kinase 1 [1-424]
Ligand
BDBM227717
Substrate
n/a
Meas. Tech.
MKNK1 Kinase High ATP Assay
pH
7.5±n/a
IC50
49±n/a nM
Comments
extracted
Citation
 Klar, U; Wortmann, L; Kettschau, G; Pühler, F; Lienau, P; Sülzle, D Substituted pyrazolopyrimidinylamino-indazoles US Patent  US9556181 Publication Date 1/31/2017 
Target
Name:
MAP kinase-interacting serine/threonine-protein kinase 1 [1-424]
Synonyms:
MAP kinase signal-integrating kinase 1 (MKNK1) | MKNK1 | MKNK1_HUMAN | MNK1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
47005.82
Organism:
Homo sapiens (Human)
Description:
aa 1-424
Residue:
424
Sequence:
MVSSQKLEKPIEMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKDKVSLCHLGWSAMAPSGLTAAPTSLGSSDPPTSASQVAGTTGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGQAPEKGLPTPQVLQRNSSTMDLTLFAAEAIALNRQLSQHEENELAEEP
  
Inhibitor
Name:
BDBM227717
Synonyms:
US9556181, 2 | n-(6-methoxy-1h-indazol-5-yl)-h-pyrazolo[3,4-d]pyrimidin-4-amine
Type:
Small organic molecule
Emp. Form.:
C13H11N7O
Mol. Mass.:
281.2727
SMILES:
COc1cc2[nH]ncc2cc1Nc1ncnc2[nH]ncc12
Structure:
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