Reaction Details
Report a problem with these data
Report a problem with these dataTarget
MAP kinase-interacting serine/threonine-protein kinase 1 [1-424]
Ligand
BDBM227721
Substrate
n/a
Meas. Tech.
MKNK1 Kinase High ATP Assay
pH
7.5±n/a
IC50
26±n/a nM
Comments
extracted
Citation
Klar, U; Wortmann, L; Kettschau, G; Pühler, F; Lienau, P; Sülzle, D Substituted pyrazolopyrimidinylamino-indazoles US Patent US9556181 Publication Date 1/31/2017 More Info.:
Target
Name:
MAP kinase-interacting serine/threonine-protein kinase 1 [1-424]
Synonyms:
MAP kinase signal-integrating kinase 1 (MKNK1) | MKNK1 | MKNK1_HUMAN | MNK1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
47005.82
Organism:
Homo sapiens (Human)
Description:
aa 1-424
Residue:
424
Sequence:
MVSSQKLEKPIEMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKDKVSLCHLGWSAMAPSGLTAAPTSLGSSDPPTSASQVAGTTGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGQAPEKGLPTPQVLQRNSSTMDLTLFAAEAIALNRQLSQHEENELAEEP
Inhibitor
Name:
BDBM227721
Synonyms:
3-bromo-n-(1h-indazol-5-yl)-1h-pyrazolo[3,4-d]pyrimidin-4-amine | US9556181, 15 | US9556181, 6 | US9556181, 9
Type:
Small organic molecule
Emp. Form.:
C12H8BrN7
Mol. Mass.:
330.143
SMILES:
Brc1n[nH]c2ncnc(Nc3ccc4[nH]ncc4c3)c12
Structure:
