Reaction Details Report a problem with these data
Target
Aldo-keto reductase family 1 member B1 [C299A]
Ligand
BDBM16419
Substrate
BDBM16418
Meas. Tech.
Enzyme Inhibition Assay
Ki
303000±n/a nM
Citation
Brownlee, JM; Carlson, E; Milne, AC; Pape, E; Harrison, DH Structural and thermodynamic studies of simple aldose reductase-inhibitor complexes. Bioorg Chem 34:424-44 (2006) [PubMed] Article
More Info.:
Target
Name:
Aldo-keto reductase family 1 member B1 [C299A]
Synonyms:
AKR1B1 | ALDR1 | ALDR_HUMAN | ALR2 | AR | Aldose Reductase (ALR2) Mutant (C299A)
Type:
Enzyme
Mol. Mass.:
35823.43
Organism:
Homo sapiens (Human)
Description:
P15121[C299A]
Residue:
316
Sequence:
MASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQEKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAKHNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVAALLSCTSHKDYPFHEEF
Inhibitor
Name:
BDBM16419
Synonyms:
2-phenylacetic acid | Benzeneacetic acid | CHEMBL1044 | Phenylacetate, XIX | Phenylacetic acid | phenylacetate
Type:
Small organic molecule
Emp. Form.:
C8H8O2
Mol. Mass.:
136.1479
SMILES:
OC(=O)Cc1ccccc1