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Target
Interleukin-1 receptor-associated kinase 1 [194-712]
Ligand
BDBM355837
Substrate
n/a
Meas. Tech.
Enzymatic Assay
IC50
550±n/a nM
Citation
 Chen, X; Yu, H; Lan, R; Jorand-Lebrun, C; Johnson, TL; Goutopoulos, A Macrocyclic compounds as IRAK1/4 inhibitors and uses thereof US Patent  US9815836 Publication Date 11/14/2017 
Target
Name:
Interleukin-1 receptor-associated kinase 1 [194-712]
Synonyms:
IRAK | IRAK1 | IRAK1_HUMAN | Interleukin-1 receptor-associated kinase 1 (IRAK1)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
55943.99
Organism:
Homo sapiens (Human)
Description:
aa 194-712
Residue:
519
Sequence:
RPFPFCWPLCEISRGTHNFSEELKIGEGGFGCVYRAVMRNTVYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAGQRAVKTHGARTKYLKDLVEEEAEEAGVALRSTQSTLQAGLAADAWAAPIAMQIYKKHLDPRPGPCPPELGLGLGQLACCCLHRRAKRRPPMTQVYERLEKLQAVVAGVPGHSEAASCIPPSPQENSYVSSTGRAHSGAAPWQPLAAPSGASAQAAEQLQRGPNQPVESDESLGGLSAALRSWHLTPSCPLDPAPLREAGCPQGDTAGESSWGSGPGSRPTAVEGLALGSSASSSSEPPQIIINPARQKMVQKLALYEDGALDSLQLLSSSSLPGLGLEQDRQGPEESDEFQS
  
Inhibitor
Name:
BDBM355837
Synonyms:
US9815836, Compound 22
Type:
Small organic molecule
Emp. Form.:
C26H34N8O3
Mol. Mass.:
506.6
SMILES:
OCCN1CCC(CC1)n1cc2NC(=O)c3cccc(n3)-c3cnn(CCCCCCNC(=O)c2n1)c3
Structure:
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