Target

Ligand

Substrate

Meas. Tech.

HTRF Kinase Inhibition Assay

pH

7.5±n/a

Temperature

295.15±n/a K

Citation

 Martin, MW; Newcomb, J; Nunes, JJ; Bemis, JE; McGowan, DC; White, RD; Buchanan, JL; DiMauro, EF; Boucher, C; Faust, T; Hsieh, F; Huang, X; Lee, JH; Schneider, S; Turci, SM; Zhu, X Discovery of novel 2,3-diarylfuro[2,3-b]pyridin-4-amines as potent and selective inhibitors of Lck: synthesis, SAR, and pharmacokinetic properties. Bioorg Med Chem Lett 17:2299-304 (2007) [PubMed]  Article Copy BDB DOI

More Info.:

Get all data from this article,   Solution Info,  Assay Method

Name:

Tyrosine-protein kinase Lck

Synonyms:

2.7.10.2 | LCK | LCK_HUMAN | LSK | Leukocyte C-terminal Src kinase | Lymphocyte cell-specific protein-tyrosine kinase | Lymphocyte-specific protein tyrosine kinase | P56-LCK | Protein YT16 | Proto-oncogene Lck | Proto-oncogene tyrosine-protein kinase LCK | Src/Lck kinase | T cell-specific protein-tyrosine kinase

Type:

n/a

Mol. Mass.:

57987.83

Organism:

Homo sapiens (Human)

Description:

P06239

Residue:

509

Sequence:

MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP

Blast this sequence in BindingDB or PDB

  
Blast E-value cutoff:

Name:

BDBM17717

Synonyms:

2,3-Diarylfuro[2,3-b]pyridine-4-amine, 13 | 2-{4-[2-(morpholin-4-yl)ethoxy]phenyl}-3-phenyl-N-[2-(piperazin-1-yl)ethyl]furo[2,3-b]pyridin-4-amine

Type:

Small organic molecule

Emp. Form.:

C31H37N5O3

Mol. Mass.:

527.6572

SMILES:

C(CN1CCNCC1)Nc1ccnc2oc(c(-c3ccccc3)c12)-c1ccc(OCCN2CCOCC2)cc1

Structure:

Search PDB for entries with ligand similarity:

Similarity to this molecule at least:

Name:

biotinylated gastrin substrate

Synonyms:

n/a

Type:

Peptide

Mol. Mass.:

2100.22

Organism:

n/a

Description:

n/a

Residue:

17

Sequence:

ITINYLEEEEAYGWLDF