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Target
Mitogen-activated protein kinase kinase kinase 8
Ligand
BDBM357015
Substrate
n/a
Meas. Tech.
Caliper Kinase Assay
IC50
11900±n/a nM
Citation
 Lloyd, J; Finlay, H; Gunaga, P; Banerjee, A; Adisechan, A Quinazolines as potassium ion channel inhibitors US Patent  US10214511 Publication Date 2/26/2019 
Target
Name:
Mitogen-activated protein kinase kinase kinase 8
Synonyms:
C-COT | COT | COT proto-oncogene serine/threonine-protein kinase | Cancer Osaka thyroid oncogene | ESTF | M3K8_HUMAN | MAP3K8 | Tpl-2 | Tumor Progression Loci-2 Kinase (COT) | Tumor progression locus 2
Type:
Serine/threonine-protein kinase
Mol. Mass.:
52916.89
Organism:
Homo sapiens (Human)
Description:
P41279
Residue:
467
Sequence:
MEYMSTGSDNKEEIDLLIKHLNVSDVIDIMENLYASEEPAVYEPSLMTMCQDSNQNDERSKSLLLSGQEVPWLSSVRYGTVEDLLAFANHISNTAKHFYGQRPQESGILLNMVITPQNGRYQIDSDVLLIPWKLTYRNIGSDFIPRGAFGKVYLAQDIKTKKRMACKLIPVDQFKPSDVEIQACFRHENIAELYGAVLWGETVHLFMEAGEGGSVLEKLESCGPMREFEIIWVTKHVLKGLDFLHSKKVIHHDIKPSNIVFMSTKAVLVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVILCRGHSTKADIYSLGATLIHMQTGTPPWVKRYPRSAYPSYLYIIHKQAPPLEDIADDCSPGMRELIEASLERNPNHRPRAADLLKHEALNPPREDQPRCQSLDSALLERKRLLSRKELELPENIADSSCTGSTEESEMLKRQRSLYIDLGALAGYFNLVRGPPTLEYG
  
Inhibitor
Name:
BDBM357015
Synonyms:
US10214511, Example 19 | US10676460, Example 19
Type:
Small organic molecule
Emp. Form.:
C20H15ClN4
Mol. Mass.:
346.813
SMILES:
Clc1nc(NCc2ccccn2)c2c(cccc2n1)-c1ccccc1
Structure:
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