Reaction Details Report a problem with these data
Target
Prostacyclin receptor
Ligand
BDBM357269
Substrate
n/a
Meas. Tech.
Homogeneous Time-Resolved Fluorescence (HTRF) Assay for Direct cAMP Measurement
EC50
7.00±n/a nM
Citation
 Tran, T; Ibarra, JB; Shin, Y; Ullman, B; Zou, N; Zeng, X Pyrazolyl substituted carbonic acid derivatives as modulators of the prostacyclin (PGI2) receptor useful for the treatment of disorders related thereto US Patent  US10214518 Publication Date 2/26/2019 
Target
Name:
Prostacyclin receptor
Synonyms:
PGI receptor | PI2R_HUMAN | PRIPR | PTGIR | Prostacyclin (IP) Receptor | Prostacyclin receptor | Prostaglandin I | Prostaglandin I2 | Prostaglandin I2 receptor | Prostanoid IP receptor
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40968.22
Organism:
Homo sapiens (Human)
Description:
The membranes prepared from human platelet were used in binding assay.
Residue:
386
Sequence:
MADSCRNLTYVRGSVGPATSTLMFVAGVVGNGLALGILSARRPARPSAFAVLVTGLAATDLLGTSFLSPAVFVAYARNSSLLGLARGGPALCDAFAFAMTFFGLASMLILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPGSWCFLRMRWAQPGGAAFSLAYAGLVALLVAAIFLCNGSVTLSLCRMYRQQKRHQGSLGPRPRTGEDEVDHLILLALMTVVMAVCSLPLTIRCFTQAVAPDSSSEMGDLLAFRFYAFNPILDPWVFILFRKAVFQRLKLWVCCLCLGPAHGDSQTPLSQLASGRRDPRAPSAPVGKEGSCVPLSAWGEGQVEPLPPTQQSSGSAVGTSSKAEASVACSLC
  
Inhibitor
Name:
BDBM357269
Synonyms:
2-(((1s,4s)-4-((5- (ethylthio)-4-(2-fluoro-3- methoxyphenyl)-3-phenyl- 1H-pyrazol-1- yl)methyl)cyclohexyl) methoxy)acetic acid | US10214518, Compound 90 | US11098034, Compound 90
Type:
Small organic molecule
Emp. Form.:
C28H33FN2O4S
Mol. Mass.:
512.636
SMILES:
CCSc1c(c(nn1C[C@@H]1CC[C@H](COCC(O)=O)CC1)-c1ccccc1)-c1cccc(OC)c1F |r,wU:9.9,12.13,(-3.23,5.5,;-2.83,4.01,;-3.92,2.92,;-3.52,1.43,;-4.6,.33,;-3.89,-1.03,;-2.37,-.78,;-2.14,.74,;-.81,1.51,;.52,.74,;.52,-.8,;1.86,-1.57,;3.19,-.8,;4.53,-1.57,;5.86,-.8,;7.19,-1.57,;8.53,-.8,;9.86,-1.57,;8.53,.74,;3.19,.74,;1.86,1.51,;-4.29,-2.52,;-5.78,-2.92,;-6.17,-4.41,;-5.09,-5.5,;-3.6,-5.1,;-3.2,-3.61,;-6.09,.73,;-7.18,-.36,;-8.66,.04,;-9.06,1.53,;-7.97,2.62,;-8.37,4.11,;-9.86,4.5,;-6.49,2.22,;-5.4,3.31,)|
Structure:
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