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Target
Glutamate--tRNA ligase
Ligand
BDBM18122
Substrate
BDBM17657
Meas. Tech.
Determination of the Inhibition Type and Constant (Ki)
pH
7.2±n/a
Temperature
310.15±n/a K
Ki
2.8 ±n/a nM
Citation
Bernier, S; Dubois, DY; Habegger-Polomat, C; Gagnon, LP; Lapointe, J; Chênevert, R Glutamylsulfamoyladenosine and pyroglutamylsulfamoyladenosine are competitive inhibitors of E. coli glutamyl-tRNA synthetase. J Enzyme Inhib Med Chem 20:61-7 (2005) [PubMed] Article
Target
Name:
Glutamate--tRNA ligase
Synonyms:
Glutamate--tRNA ligase | Glutamyl-tRNA synthetase | SYE_ECOLI | gltX | tRNA synthetase (GluRS)
Type:
Enzyme
Mol. Mass.:
53807.55
Organism:
Escherichia coli
Description:
His6-tagged clone expressed in E. coli.
Residue:
471
Sequence:
MKIKTRFAPSPTGYLHVGGARTALYSWLFARNHGGEFVLRIEDTDLERSTPEAIEAIMDGMNWLSLEWDEGPYYQTKRFDRYNAVIDQMLEEGTAYKCYCSKERLEALREEQMAKGEKPRYDGRCRHSHEHHADDEPCVVRFANPQEGSVVFDDQIRGPIEFSNQELDDLIIRRTDGSPTYNFCVVVDDWDMEITHVIRGEDHINNTPRQINILKALKAPVPVYAHVSMINGDDGKKLSKRHGAVSVMQYRDDGYLPEALLNYLVRLGWSHGDQEIFTREEMIKYFTLNAVSKSASAFNTDKLLWLNHHYINALPPEYVATHLQWHIEQENIDTRNGPQLADLVKLLGERCKTLKEMAQSCRYFYEDFAEFDADAAKKHLRPVARQPLEVVRDKLAAITDWTAENVHHAIQATADELEVGMGKVGMPLRVAVTGAGQSPALDVTVHAIGKTRSIERINKALDFIAERENQQ
Inhibitor
Name:
BDBM18122
Synonyms:
(4S)-4-amino-5-[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}sulfonyl)amino]-5-oxopentanoic acid | 5-O-[N-(L-Glutamyl)-sulfamoyl]adenosine 5 | Glu-AMS
Type:
Small organic molecule
Emp. Form.:
C15H21N7O9S
Mol. Mass.:
475.434
SMILES:
N[C@@H](CCC(O)=O)C(=O)NS(=O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12 |r|