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Target
Glutamate--tRNA ligase
Ligand
BDBM18123
Substrate
BDBM17657
Meas. Tech.
Determination of the Inhibition Type and Constant (Ki)
pH
7.2±n/a
Temperature
310.15±n/a K
Ki
15000±n/a nM
Citation
Bernier, S; Dubois, DY; Habegger-Polomat, C; Gagnon, LP; Lapointe, J; Chênevert, R Glutamylsulfamoyladenosine and pyroglutamylsulfamoyladenosine are competitive inhibitors of E. coli glutamyl-tRNA synthetase. J Enzyme Inhib Med Chem 20:61-7 (2005) [PubMed] Article
Target
Name:
Glutamate--tRNA ligase
Synonyms:
Glutamate--tRNA ligase | Glutamyl-tRNA synthetase | SYE_ECOLI | gltX | tRNA synthetase (GluRS)
Type:
Enzyme
Mol. Mass.:
53807.55
Organism:
Escherichia coli
Description:
His6-tagged clone expressed in E. coli.
Residue:
471
Sequence:
MKIKTRFAPSPTGYLHVGGARTALYSWLFARNHGGEFVLRIEDTDLERSTPEAIEAIMDGMNWLSLEWDEGPYYQTKRFDRYNAVIDQMLEEGTAYKCYCSKERLEALREEQMAKGEKPRYDGRCRHSHEHHADDEPCVVRFANPQEGSVVFDDQIRGPIEFSNQELDDLIIRRTDGSPTYNFCVVVDDWDMEITHVIRGEDHINNTPRQINILKALKAPVPVYAHVSMINGDDGKKLSKRHGAVSVMQYRDDGYLPEALLNYLVRLGWSHGDQEIFTREEMIKYFTLNAVSKSASAFNTDKLLWLNHHYINALPPEYVATHLQWHIEQENIDTRNGPQLADLVKLLGERCKTLKEMAQSCRYFYEDFAEFDADAAKKHLRPVARQPLEVVRDKLAAITDWTAENVHHAIQATADELEVGMGKVGMPLRVAVTGAGQSPALDVTVHAIGKTRSIERINKALDFIAERENQQ
Inhibitor
Name:
BDBM18123
Synonyms:
(5S)-5-{[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}sulfonyl)amino]carbonyl}pyrrolidin-2-one | 5-O-[N-(L-pyroglutamyl)-sulfamoyl]adenosine | pGluAMS
Type:
Small organic molecule
Emp. Form.:
C15H19N7O8S
Mol. Mass.:
457.418
SMILES:
Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COS(=O)(=O)NC(=O)[C@@H]2CCC(=O)N2)[C@@H](O)[C@H]1O |r|