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Target
Serine/threonine-protein kinase TBK1
Ligand
BDBM357877
Substrate
n/a
Meas. Tech.
Kinase Assays
IC50
190±n/a nM
Citation
 Showalter, HD; Saltiel, AR; Tesmer, JJ; Gan, X Amlexanox analogs US Patent  US10214536 Publication Date 2/26/2019 
Target
Name:
Serine/threonine-protein kinase TBK1
Synonyms:
NAK | NF-kappa-B-activating kinase | Protein cereblon/Serine/threonine-protein kinase TBK1 | T2K | TANK-binding kinase 1 (TBK-1) | TANK-binding kinase 1 (TBK1) | TBK1 | TBK1_HUMAN
Type:
protein
Mol. Mass.:
83645.20
Organism:
Homo sapiens (Human)
Description:
Q9UHD2
Residue:
729
Sequence:
MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFAETSDILHRMVIHVFSLQQMTAHKIYIHSYNTATIFHELVYKQTKIISSNQELIYEGRRLVLEPGRLAQHFPKTTEENPIFVVSREPLNTIGLIYEKISLPKVHPRYDLDGDASMAKAITGVVCYACRIASTLLLYQELMRKGIRWLIELIKDDYNETVHKKTEVVITLDFCIRNIEKTVKVYEKLMKINLEAAELGEISDIHTKLLRLSSSQGTIETSLQDIDSRLSPGGSLADAWAHQEGTHPKDRNVEKLQVLLNCMTEIYYQFKKDKAERRLAYNEEQIHKFDKQKLYYHATKAMTHFTDECVKKYEAFLNKSEEWIRKMLHLRKQLLSLTNQCFDIEEEVSKYQEYTNELQETLPQKMFTASSGIKHTMTPIYPSSNTLVEMTLGMKKLKEEMEGVVKELAENNHILERFGSLTMDGGLRNVDCL
  
Inhibitor
Name:
BDBM357877
Synonyms:
US10214536, Compound 53
Type:
Small organic molecule
Emp. Form.:
C19H18N2O5
Mol. Mass.:
354.3566
SMILES:
Nc1nc2oc3ccc(cc3c(=O)c2cc1C(O)=O)C1CCC(O)CC1 |(6.67,2.69,;5.33,1.93,;4,2.69,;2.67,1.93,;1.33,2.69,;,1.93,;-1.33,2.69,;-2.67,1.93,;-2.67,.38,;-1.33,-.38,;,.38,;1.33,-.38,;1.33,-1.93,;2.67,.38,;4,-.38,;5.33,.38,;6.67,-.38,;8,.38,;6.67,-1.93,;-4,-.38,;-5.33,.38,;-6.67,-.38,;-6.67,-1.93,;-8,-2.69,;-5.33,-2.69,;-4,-1.93,)|
Structure:
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