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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM359891
Substrate
n/a
Meas. Tech.
Enzyme Assay
IC50
<10±n/a nM
Citation
 Vechorkin, O; Li, Y Bicyclic heteroaromatic carboxamide compounds useful as Pim kinase inhibitors US Patent  US9822124 Publication Date 11/21/2017 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM359891
Synonyms:
N-(4-((3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperidin-1-yl)pyridin-3-yl)-3-(2,6-difluorophenyl)furo[3,2-b]pyridine-5-carboxamide | US9822124, Example 11
Type:
Small organic molecule
Emp. Form.:
C25H23F2N5O3
Mol. Mass.:
479.4786
SMILES:
C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NC(=O)c1ccc2occ(-c3c(F)cccc3F)c2n1 |r,wU:5.5,1.0,wD:7.8,(-.57,2.42,;-1.91,1.65,;-1.91,.11,;-3.24,-.66,;-4.57,.11,;-4.57,1.65,;-5.91,2.42,;-3.24,2.42,;-3.24,3.96,;-3.24,-2.2,;-4.57,-2.97,;-4.57,-4.51,;-3.24,-5.28,;-1.91,-4.51,;-1.91,-2.97,;-.57,-2.2,;.76,-2.97,;.76,-4.51,;2.1,-2.2,;3.43,-2.97,;4.76,-2.2,;4.76,-.66,;5.91,.37,;5.28,1.78,;3.75,1.62,;2.66,2.7,;1.17,2.31,;.77,.82,;.08,3.39,;.48,4.88,;1.97,5.28,;3.06,4.19,;4.55,4.59,;3.43,.11,;2.1,-.66,)|
Structure:
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