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Target
Serine/threonine-protein kinase pim-3
Ligand
BDBM359902
Substrate
n/a
Meas. Tech.
Enzyme Assay
IC50
<10±n/a nM
Citation
 Vechorkin, O; Li, Y Bicyclic heteroaromatic carboxamide compounds useful as Pim kinase inhibitors US Patent  US9822124 Publication Date 11/21/2017 
Target
Name:
Serine/threonine-protein kinase pim-3
Synonyms:
PIM3 | PIM3_HUMAN | Serine/threonine-protein kinase pim-3 (PIM3)
Type:
Protein
Mol. Mass.:
35888.19
Organism:
Homo sapiens (Human)
Description:
Q86V86
Residue:
326
Sequence:
MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDLRSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGGVPESCDLRLCTLDPDDVASTTSSSESL
  
Inhibitor
Name:
BDBM359902
Synonyms:
N-(4-((3S,5R)-3-Amino-5-methylpiperidin-1-yl)pyridin-3-yl)-3-(2-fluorophenyl)furo[3,2-b]pyridine-5-carboxamide | US9822124, Example 21
Type:
Small organic molecule
Emp. Form.:
C25H24FN5O2
Mol. Mass.:
445.4888
SMILES:
C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NC(=O)c1ccc2occ(-c3ccccc3F)c2n1 |r|
Structure:
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