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Target
Cytosolic arginine sensor for mTORC1 subunit 1
Ligand
BDBM315557
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
<25±n/a nM
Citation
 Ren, P; Liu, Y; Li, L; Chan, K; Wilson, TE Kinase inhibitors and methods of use US Patent  US9828378 Publication Date 11/28/2017 
Target
Name:
Cytosolic arginine sensor for mTORC1 subunit 1
Synonyms:
CAST1_HUMAN | CASTOR1 | Cellular arginine sensor for mTORC1 protein 1 | GATS-like protein 3 | GATSL3 | mTORC1 protein 1
Type:
Protein
Mol. Mass.:
36264.36
Organism:
Homo sapiens (Human)
Description:
Q8WTX7
Residue:
329
Sequence:
MELHILEHRVRVLSVARPGLWLYTHPLIKLLFLPRRSRCKFFSLTETPEDYTLMVDEEGFKELPPSEFLQVAEATWLVLNVSSHSGAAVQAAGVTKIARSVIAPLAEHHVSVLMLSTYQTDFILVREQDLSVVIHTLAQEFDIYREVGGEPVPVTRDDSSNGFPRTQHGPSPTVHPIQSPQNRFCVLTLDPETLPAIATTLIDVLFYSHSTPKEAASSSPEPSSITFFAFSLIEGYISIVMDAETQKKFPSDLLLTSSSGELWRMVRIGGQPLGFDECGIVAQIAGPLAAADISAYYISTFNFDHALVPEDGIGSVIEVLQRRQEGLAS
  
Inhibitor
Name:
BDBM315557
Synonyms:
US10172858, Table 2.54 | US9828378, # 54
Type:
Small organic molecule
Emp. Form.:
C17H16N6O2
Mol. Mass.:
336.3479
SMILES:
Nc1ncnc2n(nc(-c3cc4cc(O)ccc4[nH]3)c12)C1CC(O)C1 |(-2.24,1.62,;-2.24,.08,;-3.57,-.69,;-3.57,-2.23,;-2.24,-3,;-.9,-2.23,;.56,-2.71,;1.47,-1.46,;.56,-.22,;.96,1.27,;.06,2.52,;.96,3.76,;.64,5.27,;1.79,6.3,;1.39,7.79,;3.25,5.82,;3.57,4.32,;2.43,3.29,;2.43,1.75,;-.9,-.69,;.96,-4.2,;.19,-5.53,;1.52,-6.3,;1.92,-7.79,;2.29,-4.97,)|
Structure:
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