Reaction Details Report a problem with these data
Target
Cytosolic arginine sensor for mTORC1 subunit 1
Ligand
BDBM315560
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
<25±n/a nM
Citation
 Ren, P; Liu, Y; Li, L; Chan, K; Wilson, TE Kinase inhibitors and methods of use US Patent  US9828378 Publication Date 11/28/2017 
Target
Name:
Cytosolic arginine sensor for mTORC1 subunit 1
Synonyms:
CAST1_HUMAN | CASTOR1 | Cellular arginine sensor for mTORC1 protein 1 | GATS-like protein 3 | GATSL3 | mTORC1 protein 1
Type:
Protein
Mol. Mass.:
36264.36
Organism:
Homo sapiens (Human)
Description:
Q8WTX7
Residue:
329
Sequence:
MELHILEHRVRVLSVARPGLWLYTHPLIKLLFLPRRSRCKFFSLTETPEDYTLMVDEEGFKELPPSEFLQVAEATWLVLNVSSHSGAAVQAAGVTKIARSVIAPLAEHHVSVLMLSTYQTDFILVREQDLSVVIHTLAQEFDIYREVGGEPVPVTRDDSSNGFPRTQHGPSPTVHPIQSPQNRFCVLTLDPETLPAIATTLIDVLFYSHSTPKEAASSSPEPSSITFFAFSLIEGYISIVMDAETQKKFPSDLLLTSSSGELWRMVRIGGQPLGFDECGIVAQIAGPLAAADISAYYISTFNFDHALVPEDGIGSVIEVLQRRQEGLAS
  
Inhibitor
Name:
BDBM315560
Synonyms:
US10172858, Table 2.57 | US9828378, # 57
Type:
Small organic molecule
Emp. Form.:
C23H27N7O2
Mol. Mass.:
433.5062
SMILES:
Nc1ncnc2n(nc(-c3cc4cc(O)ccc4[nH]3)c12)C1CCC(CC1)N1CCOCC1 |w:23.30,(-2.24,3.7,;-2.24,2.16,;-3.57,1.39,;-3.57,-.15,;-2.24,-.92,;-.9,-.15,;.56,-.63,;1.47,.62,;.56,1.86,;.96,3.35,;.06,4.6,;.96,5.84,;.64,7.35,;1.79,8.38,;1.39,9.87,;3.25,7.9,;3.57,6.4,;2.43,5.37,;2.43,3.83,;-.9,1.39,;.56,-2.17,;-.77,-2.94,;-.77,-4.48,;.56,-5.25,;1.9,-4.48,;1.9,-2.94,;.56,-6.79,;-.77,-7.56,;-.77,-9.1,;.56,-9.87,;1.9,-9.1,;1.9,-7.56,)|
Structure:
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