Reaction Details Report a problem with these data
Target
Metallo-beta-lactamase type 2
Ligand
BDBM361144
Substrate
n/a
Meas. Tech.
BIOLOGICAL ASSAYS
IC50
0.016±n/a nM
Citation
Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Metallo-beta-lactamase inhibitors US Patent US10221163 Publication Date 3/5/2019
More Info.:
Target
Name:
Metallo-beta-lactamase type 2
Synonyms:
B2 metallo-beta-lactamase | BLAN1_KLEPN | Beta-lactamase NDM-1 | Beta-lactamase type II | Metallo-beta-lactamase NDM-1 | Metallo-beta-lactamase type 2 | Metallo-beta-lactamase type II | NDM-1 | New Delhi metallo-beta-lactamase-1 | blaNDM-1
Type:
PROTEIN
Mol. Mass.:
28498.15
Organism:
Klebsiella pneumoniae
Description:
ChEMBL_103887
Residue:
270
Sequence:
MELPNIMHPVAKLSTALAAALMLSGCMPGEIRPTIGQQMETGDQRFGDLVFRQLAPNVWQHTSYLDMPGFGAVASNGLIVRDGGRVLVVDTAWTDDQTAQILNWIKQEINLPVALAVVTHAHQDKMGGMDALHAAGIATYANALSNQLAPQEGMVAAQHSLTFAANGWVEPATAPNFGPLKVFYPGPGHTSDNITVGIDGTDIAFGGCLIKDSKAKSLGNLGDADTEHYAASARAFGAAFPKASMIVMSHSAPDSRAAITHTARMADKLR
Inhibitor
Name:
BDBM361144
Synonyms:
(R)-4-(1H- benzo[d]imidazol-4-yl)- N1-(3-amino-2- hydroxypropyl)-3-(2H- tetrazol-5-yl)-benzene-1,2- disulfonamide | US10221163, Example 301 | US10544130, Example 301
Type:
Small organic molecule
Emp. Form.:
C17H19N9O5S2
Mol. Mass.:
493.52
SMILES:
NC[C@@H](O)CNS(=O)(=O)c1ccc(-c2cccc3[nH]cnc23)c(-c2nn[nH]n2)c1S(N)(=O)=O |r|