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Target
Amine oxidase [flavin-containing] A
Ligand
BDBM19165
Substrate
BDBM10990
Meas. Tech.
MAO Inhibition Assay
pH
7.4±n/a
Temperature
310.15±n/a K
IC50
>100000±n/a nM
Citation
 Carotti, A; Catto, M; Leonetti, F; Campagna, F; Soto-Otero, R; Méndez-Alvarez, E; Thull, U; Testa, B; Altomare, C Synthesis and monoamine oxidase inhibitory activity of new pyridazine-, pyrimidine- and 1,2,4-triazine-containing tricyclic derivatives. J Med Chem 50:5364-71 (2007) [PubMed]  Article 
Target
Name:
Amine oxidase [flavin-containing] A
Synonyms:
AOFA_RAT | Amine oxidase (flavin-containing) A | Amine oxidase [flavin-containing] A | Maoa | Monoamine Oxidase Type A (MAO-A) | Monoamine oxidase | Monoamine oxidase A (MAO-A) | Monoamine oxidase A (rMAO-A) | Monoamine oxidase type A (MAOA)
Type:
Enzyme
Mol. Mass.:
59515.21
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
526
Sequence:
MTDLEKPNLAGHMFDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVDVGGAYVGPTQNRILRLSKELGIETYKVNVNERLVQYVKGKTYPFRGAFPPVWNPLAYLDYNNLWRTMDEMGKEIPVDAPWQARHAQEWDKMTMKDLIDKICWTKTAREFAYLFVNINVTSEPHEVSALWFLWYVRQCGGTARIFSVTNGGQERKFVGGSGQVSEQIMGLLGDKVKLSSPVTYIDQTDDNIIVETLNHEHYECKYVISAIPPILTAKIHFKPELPPERNQLIQRLPMGAVIKCMVYYKEAFWKKKDYCGCMIIEDEEAPIAITLDDTKPDGSLPAIMGFILARKADRQAKLHKDIRKRKICELYAKVLGSQEALYPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYGRVIRQPVGRIYFAGTETATQWSGYMEGAVEAGERAAREVLNALGKVAKKDIWVEEPESKDVPAIEITHTFLERNLPSVPGLLKITGVSTSVALLCFVLYKIKKLPC
  
Inhibitor
Name:
BDBM19165
Synonyms:
3-phenyl-5H-indeno[1,2-c]pyridazine | Aza-heterocyclic Derivative, 1c | CHEMBL129769
Type:
Small organic molecule
Emp. Form.:
C17H12N2
Mol. Mass.:
244.2906
SMILES:
C1c2ccccc2-c2nnc(cc12)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM10990
Synonyms:
3-amino-1-(2-aminophenyl)propan-1-one | Diaminopropiophenone | Kynuramine
Type:
Small organic molecule
Emp. Form.:
C9H12N2O
Mol. Mass.:
164.2044
SMILES:
NCCC(=O)c1ccccc1N
Structure:
Search PDB for entries with ligand similarity: