Reaction Details Report a problem with these data
Target
Histone deacetylase 3
Ligand
BDBM19427
Substrate
BDBM19411
Meas. Tech.
HDAC Enzyme Activity Assay
IC50
>20000±n/a nM
Citation
Moradei, OM; Mallais, TC; Frechette, S; Paquin, I; Tessier, PE; Leit, SM; Fournel, M; Bonfils, C; Trachy-Bourget, MC; Liu, J; Yan, TP; Lu, AH; Rahil, J; Wang, J; Lefebvre, S; Li, Z; Vaisburg, AF; Besterman, JM Novel aminophenyl benzamide-type histone deacetylase inhibitors with enhanced potency and selectivity. J Med Chem 50:5543-6 (2007) [PubMed] Article
More Info.:
Target
Name:
Histone deacetylase 3
Synonyms:
HD3 | HDAC3 | HDAC3_HUMAN | Histone deacetylase 3 (HDAC3) | Human HDAC3 | RPD3-2 | SMAP45
Type:
Enzyme
Mol. Mass.:
48829.55
Organism:
Homo sapiens (Human)
Description:
O15379
Residue:
428
Sequence:
MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCRFHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNNKICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDNDKESDVEI
Inhibitor
Name:
BDBM19427
Synonyms:
N-[2-amino-5-(thiophen-2-yl)phenyl]-4-methoxybenzamide | benzamide-type inhibitor, 23
Type:
Small organic molecule
Emp. Form.:
C18H16N2O2S
Mol. Mass.:
324.397
SMILES:
COc1ccc(cc1)C(=O)Nc1cc(ccc1N)-c1cccs1