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Target
Histone deacetylase 8
Ligand
BDBM19427
Substrate
BDBM19411
Meas. Tech.
HDAC Enzyme Activity Assay
IC50
>20000±n/a nM
Citation
 Moradei, OM; Mallais, TC; Frechette, S; Paquin, I; Tessier, PE; Leit, SM; Fournel, M; Bonfils, C; Trachy-Bourget, MC; Liu, J; Yan, TP; Lu, AH; Rahil, J; Wang, J; Lefebvre, S; Li, Z; Vaisburg, AF; Besterman, JM Novel aminophenyl benzamide-type histone deacetylase inhibitors with enhanced potency and selectivity. J Med Chem 50:5543-6 (2007) [PubMed]  Article 
Target
Name:
Histone deacetylase 8
Synonyms:
HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8
Type:
Enzyme
Mol. Mass.:
41749.60
Organism:
Homo sapiens (Human)
Description:
Q9BY41
Residue:
377
Sequence:
MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
  
Inhibitor
Name:
BDBM19427
Synonyms:
N-[2-amino-5-(thiophen-2-yl)phenyl]-4-methoxybenzamide | benzamide-type inhibitor, 23
Type:
Small organic molecule
Emp. Form.:
C18H16N2O2S
Mol. Mass.:
324.397
SMILES:
COc1ccc(cc1)C(=O)Nc1cc(ccc1N)-c1cccs1
Structure:
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Substrate
Name:
BDBM19411
Synonyms:
BDBM24625 | Boc-Lys(Ac)-AMC | fluorescent substrate
Type:
n/a
Emp. Form.:
C23H31N3O6
Mol. Mass.:
445.5087
SMILES:
CC(=O)NCCCC[C@H](NC(=O)OC(C)(C)C)C(=O)Nc1ccc2c(C)cc(=O)oc2c1
Structure:
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