Reaction Details Report a problem with these data
Target
Cathepsin K
Ligand
BDBM19758
Substrate
BDBM19485
Meas. Tech.
Enzyme Inhibition Assay
pH
7±n/a
Temperature
295.15±n/a K
IC50
240±n/a nM
Citation
Altmann, E; Aichholz, R; Betschart, C; Buhl, T; Green, J; Lattmann, R; Missbach, M Dipeptide nitrile inhibitors of cathepsin K. Bioorg Med Chem Lett 16:2549-54 (2006) [PubMed] Article
Target
Name:
Cathepsin K
Synonyms:
CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X
Type:
Enzyme
Mol. Mass.:
36975.68
Organism:
Homo sapiens (Human)
Description:
P43235
Residue:
329
Sequence:
MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM
Inhibitor
Name:
BDBM19758
Synonyms:
benzyl N-[(1S)-1-{[(1R)-2-(tert-butoxy)-1-cyanoethyl]carbamoyl}-3-methylbutyl]carbamate | dipeptidyl nitrile, 5g
Type:
Small organic molecule
Emp. Form.:
C21H31N3O4
Mol. Mass.:
389.4885
SMILES:
CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](COC(C)(C)C)C#N |r|