Reaction Details Report a problem with these data
Target
Papain
Ligand
BDBM20118
Substrate
BDBM20081
Meas. Tech.
Papain Inhibition Assay
Ki
380±n/a nM
Citation
 Löser, R; Schilling, K; Dimmig, E; Gütschow, M Interaction of papain-like cysteine proteases with dipeptide-derived nitriles. J Med Chem 48:7688-707 (2005) [PubMed]  Article 
Target
Name:
Papain
Synonyms:
Allergen=Car p 1 | PAPA1_CARPA | PPI | Papaya proteinase I
Type:
Enzyme
Mol. Mass.:
38923.01
Organism:
Carica papaya
Description:
Papain was purchased from Sigma, Germany.
Residue:
345
Sequence:
MAMIPSISKLLFVAICLFVYMGLSFGDFSIVGYSQNDLTSTERLIQLFESWMLKHNKIYKNIDEKIYRFEIFKDNLKYIDETNKKNNSYWLGLNVFADMSNDEFKEKYTGSIAGNYTTTELSYEEVLNDGDVNIPEYVDWRQKGAVTPVKNQGSCGSCWAFSAVVTIEGIIKIRTGNLNEYSEQELLDCDRRSYGCNGGYPWSALQLVAQYGIHYRNTYPYEGVQRYCRSREKGPYAAKTDGVRQVQPYNEGALLYSIANQPVSVVLEAAGKDFQLYRGGIFVGPCGNKVDHAVAAVGYGPNYILIKNSWGTGWGENGYIRIKRGTGNSYGVCGLYTSSFYPVKN
  
Inhibitor
Name:
BDBM20118
Synonyms:
(2S)-N-(cyanomethyl)-2-acetamido-3-phenylpropanamide | phenylalanine derivative, 42
Type:
Small organic molecule
Emp. Form.:
C13H15N3O2
Mol. Mass.:
245.2771
SMILES:
CC(=O)N[C@@H](Cc1ccccc1)C(=O)NCC#N |r|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM20081
Synonyms:
Z-Phe-Arg-NH-4-nitrophenyl | Z-Phe-Arg-NHNp
Type:
n/a
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
n/a
Structure: