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Target
Programmed cell death 1 ligand 1
Ligand
BDBM365935
Substrate
n/a
Meas. Tech.
Homogenous Time-Resolved Fluorescence (HTRF) Binding Assay
IC50
555±n/a nM
Citation
 Chupak, LS; Zheng, X Compounds useful as immunomodulators US Patent  US9872852 Publication Date 1/23/2018 
Target
Name:
Programmed cell death 1 ligand 1
Synonyms:
B7 homolog 1 | B7-H1 | B7H1 | B7H1 | CD274 | CD_antigen=CD274 | PD-L1 | PD1L1_HUMAN | PDCD1 ligand 1 | PDCD1L1 | PDCD1LG1 | PDL1 | Programmed cell death 1 ligand 1 | Programmed death ligand 1
Type:
PROTEIN
Mol. Mass.:
33278.49
Organism:
Homo sapiens (Human)
Description:
ChEMBL_109807
Residue:
290
Sequence:
MRIFAVFIFMTYWHLLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIVYWEMEDKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAGVYRCMISYGGADYKRITVKVNAPYNKINQRILVVDPVTSEHELTCQAEGYPKAEVIWTSSDHQVLSGKTTTTNSKREEKLFNVTSTLRINTTTNEIFYCTFRRLDPEENHTAELVIPELPLAHPPNERTHLVILGAILLCLGVALTFIFRLRKGRMMDVKKCGIQDTNSKKQSDTHLEET
  
Inhibitor
Name:
BDBM365935
Synonyms:
US9872852, Example 187 | [(3,3- difluorocyclobutyl)methyl]({2,6- dimethoxy-4-[(2-methyl-3- phenylphenyl)methoxy]phenyl} methyl)amine
Type:
Small organic molecule
Emp. Form.:
C28H31F2NO3
Mol. Mass.:
467.5474
SMILES:
COc1cc(OCc2cccc(c2C)-c2ccccc2)cc(OC)c1CNCC1CC(F)(F)C1
Structure:
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