Reaction Details Report a problem with these data
Target
Interleukin-21
Ligand
BDBM247033
Substrate
n/a
IC50
<10000±n/a nM
Citation
 Gaweco, A; Tilley, J; Blinn, J Sulfonamide retinoic acid receptor-related orphan receptor modulators and uses thereof US Patent  US9701663 Publication Date 7/11/2017 
Target
Name:
Interleukin-21
Synonyms:
IL21 | IL21_HUMAN | Za11 | il-21
Type:
Enzyme Catalytic Domain
Mol. Mass.:
17933.60
Organism:
Homo sapiens (Human)
Description:
Q9HBE4
Residue:
162
Sequence:
MRSSPGNMERIVICLMVIFLGTLVHKSSSQGQDRHMIRMRQLIDIVDQLKNYVNDLVPEFLPAPEDVETNCEWSAFSCFQKAQLKSANTGNNERIINVSIKKLKRKPPSTNAGRRQKHRLTCPSCDSYEKKPPKEFLERFKSLLQKMIHQHLSSRTHGSEDS
  
Inhibitor
Name:
BDBM247033
Synonyms:
US9701663, 48 | rac.-trans-1-((-5-methyl-1-(phenylsulfonyl)pyrrolidin-3-yl)methyl)-5-(1H-pyrazol-4-yl)-1H-indole
Type:
Small organic molecule
Emp. Form.:
C23H24N4O2S
Mol. Mass.:
420.527
SMILES:
C[C@H]1CC(Cn2ccc3cc(ccc23)-c2cn[nH]c2)CN1S(=O)(=O)c1ccccc1 |r|
Structure:
Search PDB for entries with ligand similarity: