Reaction Details Report a problem with these data
Target
Ghrelin O-acyltransferase
Ligand
BDBM367611
Substrate
n/a
Meas. Tech.
Human GOAT Enzymatic Assay
IC50
574±0 nM
Citation
Galka, CS; Hembre, EJ; Honigschmidt, NA; Martinez-Grau, MA; Plaza, GR; Rubio, A; Keding, SJ; Smith, DL Ghrelin 0-acyl transferase inhibitors US Patent US10227310 Publication Date 3/12/2019
More Info.:
Target
Name:
Ghrelin O-acyltransferase
Synonyms:
GOAT | Ghrelin O-acyltransferase (GOAT) | MBOA4_HUMAN | MBOAT4 | Membrane-bound O-acyltransferase domain-containing protein 4 | O-acyltransferase domain-containing protein 4 | OACT4
Type:
Enzyme
Mol. Mass.:
49733.10
Organism:
Homo sapiens (Human)
Description:
Q96T53
Residue:
435
Sequence:
MEWLWLFFLHPISFYQGAAFPFALLFNYLCIMDSFSTRARYLFLLTGGGALAVAAMGSYAVLVFTPAVCAVALLCSLAPQQVHRWTFCFQMSWQTLCHLGLHYTEYYLHEPPSVRFCITLSSLMLLTQRVTSLSLDICEGKVKAASGGFRSRSSLSEHVCKALPYFSYLLFFPALLGGSLCSFQRFQARVQGSSALHPRHSFWALSWRGLQILGLECLNVAVSRVVDAGAGLTDCQQFECIYVVWTTAGLFKLTYYSHWILDDSLLHAAGFGPELGQSPGEEGYVPDADIWTLERTHRISVFSRKWNQSTARWLRRLVFQHSRAWPLLQTFAFSAWWHGLHPGQVFGFVCWAVMVEADYLIHSFANEFIRSWPMRLFYRTLTWAHTQLIIAYIMLAVEVRSLSSLWLLCNSYNSVFPMVYCILLLLLAKRKHKCN
Inhibitor
Name:
BDBM367611
Synonyms:
N-[(1S)-2-[(4R,S)- 4-[2-(4-Amino-6- chloro-2-methyl- pyrimidin-5-yl)ethyl] azepan-1-yl]-1- methyl-2-oxo-ethyl] pyridine-4-carboxamide | US10227310, Example 37
Type:
Small organic molecule
Emp. Form.:
C22H29ClN6O2
Mol. Mass.:
444.958
SMILES:
C[C@H](NC(=O)c1ccncc1)C(=O)N1CCCC(CCc2c(N)nc(C)nc2Cl)CC1 |r|