Reaction Details Report a problem with these data
Target
Metallo-beta-lactamase GIM-1
Ligand
BDBM367675
Substrate
n/a
Meas. Tech.
MBL Inhibitory Activity in Constructed E. coli Cells Expressing MBLs
IC50
610±n/a nM
Citation
 Rongved, P; Åstrand, OA; Bayer, A; Leiros, HS; Samuelsen, null; Edvardsen, KS; Muhammad, Z Inhibitors of metallo-beta-lactamase (MBL) comprising a zinc chelating moiety US Patent  US10227327 Publication Date 3/12/2019 
Target
Name:
Metallo-beta-lactamase GIM-1
Synonyms:
GIM-1 | GIM-1 protein | Metallo-beta-lactamase GIM-1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
27418.35
Organism:
Pseudomonas aeruginosa
Description:
n/a
Residue:
250
Sequence:
MKNVLVFLILLVALPALAQGHKPLEVIKIEDGVYLHTSFKNIEGYGLVDSNGLVVLDNNQAYIIDTPWSEEDTKLLLSWATDRGYQVMASISTHSHEDRTAGIKLLNSKSIPTYTSELTKKLLAREGKPVPTHYFKDDEFTLGNGLIELYYPGAGHTEDNIVAWLPKSKILFGGCLVRSHEWEGLGYVGDASISSWADSIKNIVSKKYPIQMVVPGHGKVGSSDILDHTIDLAESASNKLMQPTAEASAD
  
Inhibitor
Name:
BDBM367675
Synonyms:
N,N,N′,N′-Tetrakis(2-pyridinylmethyl)-1,2-ethanediamine | US10227327, TPEN
Type:
Small organic molecule
Emp. Form.:
C26H28N6
Mol. Mass.:
424.5407
SMILES:
C(CN(Cc1ccccn1)Cc1ccccn1)N(Cc1ccccn1)Cc1ccccn1
Structure:
Search PDB for entries with ligand similarity: