Reaction Details Report a problem with these data
Target
Metallo-beta-lactamase GIM-1
Ligand
BDBM367681
Substrate
n/a
Meas. Tech.
MBL Inhibitory Activity in Constructed E. coli Cells Expressing MBLs
IC50
140±n/a nM
Citation
 Rongved, P; Åstrand, OA; Bayer, A; Leiros, HS; Samuelsen, null; Edvardsen, KS; Muhammad, Z Inhibitors of metallo-beta-lactamase (MBL) comprising a zinc chelating moiety US Patent  US10227327 Publication Date 3/12/2019 
Target
Name:
Metallo-beta-lactamase GIM-1
Synonyms:
GIM-1 | GIM-1 protein | Metallo-beta-lactamase GIM-1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
27418.35
Organism:
Pseudomonas aeruginosa
Description:
n/a
Residue:
250
Sequence:
MKNVLVFLILLVALPALAQGHKPLEVIKIEDGVYLHTSFKNIEGYGLVDSNGLVVLDNNQAYIIDTPWSEEDTKLLLSWATDRGYQVMASISTHSHEDRTAGIKLLNSKSIPTYTSELTKKLLAREGKPVPTHYFKDDEFTLGNGLIELYYPGAGHTEDNIVAWLPKSKILFGGCLVRSHEWEGLGYVGDASISSWADSIKNIVSKKYPIQMVVPGHGKVGSSDILDHTIDLAESASNKLMQPTAEASAD
  
Inhibitor
Name:
BDBM367681
Synonyms:
1-(pyridin-2-yl)-N-(pyridin-2-ylmethyl)-N-((1-(3,4,5-trimethoxybenzyl)-1H-1,2,3-triazol-4-yl)methyl)methanamine (OAA4073) | US10227327, Example 7
Type:
Small organic molecule
Emp. Form.:
C25H28N6O3
Mol. Mass.:
460.5282
SMILES:
COc1cc(Cn2cc(CN(Cc3ccccn3)Cc3ccccn3)nn2)cc(OC)c1OC
Structure:
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