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Target
VIM-1 protein
Ligand
BDBM368058
Substrate
n/a
Meas. Tech.
Enzyme Activity
IC50
0.139±n/a nM
Citation
 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Metallo-beta-lactamase inhibitors US Patent  US10227331 Publication Date 3/12/2019 
Target
Name:
VIM-1 protein
Synonyms:
Beta-lactamase VIM-1 | Class B carbapenemase VIM-1 | Metallo-beta-lactamase VIM-1 | Metallobeta-lactamase | VIM-1 | VIM-1 metallo-beta lactamase | VIM-1 metallo-beta-lactamase | VIM-1 protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
28014.53
Organism:
Pseudomonas aeruginosa
Description:
n/a
Residue:
266
Sequence:
MLKVISSLLVYMTASVMAVASPLAHSGEPSGEYPTVNEIPVGEVRLYQIADGVWSHIATQSFDGAVYPSNGLIVRDGDELLLIDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHDDRVGGVDVLRAAGVATYASPSTRRLAEAEGNEIPTHSLEGLSSSGDAVRFGPVELFYPGAAHSTDNLVVYVPSANVLYGGCAVHELSSTSAGNVADADLAEWPTSVERIQKHYPEAEVVIPGHGLPGGLDLLQHTANVVKAHKNRSVAE
  
Inhibitor
Name:
BDBM368058
Synonyms:
3-((4′-(Cyclopropanesulfonamido)-3-sulfamoyl-2-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)sulfonyl)-N-cyclopropylazetidine-1-carboxamide and 3-((4′-(cyclopropanesulfonamido)-3-sulfamoyl-2-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)sulfonyl)azetidine-1-carboxamide | US10227331, Example 245 | US10227331, Example 246
Type:
Small organic molecule
Emp. Form.:
C23H26N8O7S3
Mol. Mass.:
622.697
SMILES:
NS(=O)(=O)c1c(ccc(-c2ccc(NS(=O)(=O)C3CC3)cc2)c1-c1nn[nH]n1)S(=O)(=O)C1CN(C1)C(=O)NC1CC1
Structure:
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