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Target
VIM-1 protein
Ligand
BDBM367963
Substrate
n/a
Meas. Tech.
Enzyme Activity
IC50
0.162±n/a nM
Citation
 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Metallo-beta-lactamase inhibitors US Patent  US10227331 Publication Date 3/12/2019 
Target
Name:
VIM-1 protein
Synonyms:
Beta-lactamase VIM-1 | Class B carbapenemase VIM-1 | Metallo-beta-lactamase VIM-1 | Metallobeta-lactamase | VIM-1 | VIM-1 metallo-beta lactamase | VIM-1 metallo-beta-lactamase | VIM-1 protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
28014.53
Organism:
Pseudomonas aeruginosa
Description:
n/a
Residue:
266
Sequence:
MLKVISSLLVYMTASVMAVASPLAHSGEPSGEYPTVNEIPVGEVRLYQIADGVWSHIATQSFDGAVYPSNGLIVRDGDELLLIDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHDDRVGGVDVLRAAGVATYASPSTRRLAEAEGNEIPTHSLEGLSSSGDAVRFGPVELFYPGAAHSTDNLVVYVPSANVLYGGCAVHELSSTSAGNVADADLAEWPTSVERIQKHYPEAEVVIPGHGLPGGLDLLQHTANVVKAHKNRSVAE
  
Inhibitor
Name:
BDBM367963
Synonyms:
2-((4-(2-oxo-2,3- dihydro-1H- benzo[d]imidazol-4-yl)- 2-sulfamoyl-3-(1H- tetrazol-5- yl)phenyl)sulfonyl) ethanaminium 2,2,2- trifluoroacetate | US10227331, Example 150 | US10227331, Example 300
Type:
Small organic molecule
Emp. Form.:
C16H16N8O5S2
Mol. Mass.:
464.479
SMILES:
NCCS(=O)(=O)c1ccc(-c2cccc3[nH]c(=O)[nH]c23)c(-c2nnn[nH]2)c1S(N)(=O)=O
Structure:
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