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Target
Proto-oncogene tyrosine-protein kinase Src
Ligand
BDBM247129
Substrate
n/a
Meas. Tech.
c-Src Enzyme Inhibition 1
IC50
<1.30±n/a nM
Citation
 Cariou, CA; Charron, CE; Fordyce, EA; Hamza, D; Fyfe, MC; Ito, K; King-Underwood, J; Murray, PJ; Onions, ST; Thom, SM; Watson, HT; Williams, JG Pyrazolyl-ureas as kinase inhibitors US Patent  US9701670 Publication Date 7/11/2017 
Target
Name:
Proto-oncogene tyrosine-protein kinase Src
Synonyms:
Calmodulin/Proto-oncogene tyrosine-protein kinase Src | Protein cereblon/Tyrosine-protein kinase SRC | Proto-oncogene c-Src | Proto-oncogene tyrosine-protein kinase Src (c-Src) | SRC | SRC1 | SRC_HUMAN | Tyrosine-protein kinase Src (SRC) | V-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | c-Src | p60-Src | pp60c-src
Type:
Protein
Mol. Mass.:
59838.60
Organism:
Homo sapiens (Human)
Description:
P12931
Residue:
536
Sequence:
MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAEPKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
  
Inhibitor
Name:
BDBM247129
Synonyms:
3-((6-(4-(3-(3-(tert-Butyl)-1-(4-methoxyphenyl)-1H-pyrazol-5-yl)ureido)-2,3-dimethylphenoxy)pyrimidin-4-yl)amino)-5-methoxy-N-(2-morpholinoethyl)benzamide | US9701670, 91
Type:
Small organic molecule
Emp. Form.:
C41H49N9O6
Mol. Mass.:
763.8845
SMILES:
COc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2cc(Nc3cc(OC)cc(c3)C(=O)NCCN3CCOCC3)ncn2)c(C)c1C)C(C)(C)C
Structure:
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