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Target
Phosphatidylinositol 3-kinase regulatory subunit beta
Ligand
BDBM368704
Substrate
n/a
Meas. Tech.
TR-FRET Assay
IC50
4.00±n/a nM
Citation
 Chandrasekhar, J; Patel, L; Perreault, S; Phillips, G; Till, NA; Treiberg, JA Phosphatidylinositol 3-kinase inhibitors US Patent  US10227350 Publication Date 3/12/2019 
Target
Name:
Phosphatidylinositol 3-kinase regulatory subunit beta
Synonyms:
P85B_HUMAN | PI3-kinase regulatory subunit beta | PI3-kinase subunit p85-beta | PI3K regulatory subunit beta | PIK3R2 | Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta | PtdIns-3-kinase regulatory subunit beta | PtdIns-3-kinase regulatory subunit p85-beta
Type:
Enzyme Subunit
Mol. Mass.:
81542.75
Organism:
Homo sapiens (Human)
Description:
O00459
Residue:
728
Sequence:
MAGPEGFQYRALYPFRRERPEDLELLPGDVLVVSRAALQALGVAEGGERCPQSVGWMPGLNERTRQRGDFPGTYVEFLGPVALARPGPRPRGPRPLPARPRDGAPEPGLTLPDLPEQFSPPDVAPPLLVKLVEAIERTGLDSESHYRPELPAPRTDWSLSDVDQWDTAALADGIKSFLLALPAPLVTPEASAEARRALREAAGPVGPALEPPTLPLHRALTLRFLLQHLGRVASRAPALGPAVRALGATFGPLLLRAPPPPSSPPPGGAPDGSEPSPDFPALLVEKLLQEHLEEQEVAPPALPPKPPKAKPASTVLANGGSPPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSKIQGEYTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVDLINHYRHESLAQYNAKLDTRLLYPVSKYQQDQIVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTAIEAFNETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHESRTKLEQQLRAQASDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQKKINEWLGIKNETEDQYALMEDEDDLPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQRGCYACSVVVDGDTKHCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHPVRAPGPGPPPAAR
  
Inhibitor
Name:
BDBM368704
Synonyms:
US10227350, Compound 119 | US10227350, Compound 120 | US10227350, Compound 161
Type:
Small organic molecule
Emp. Form.:
C24H15Cl2FN8
Mol. Mass.:
505.334
SMILES:
Cc1nc2c(cc(cc2n1-c1ccnc2c(Cl)ccc(Cl)c12)-c1ccnc(N)c1F)-c1nnc[nH]1 |(-6,-.24,;-4.46,-.24,;-3.98,-1.7,;-2.44,-1.7,;-1.41,-2.85,;.1,-2.53,;.57,-1.06,;-.46,.08,;-1.97,-.24,;-3.21,.67,;-3.21,2.21,;-1.88,2.98,;-1.88,4.52,;-3.21,5.29,;-4.54,4.52,;-5.88,5.29,;-5.88,6.83,;-7.21,4.52,;-7.21,2.98,;-5.88,2.21,;-5.88,.67,;-4.54,2.98,;2.06,-.66,;2.46,.82,;3.95,1.22,;5.03,.13,;4.64,-1.35,;5.72,-2.44,;3.15,-1.75,;2.75,-3.24,;-1.81,-4.33,;-.9,-5.58,;-1.81,-6.83,;-3.27,-6.35,;-3.27,-4.81,)|
Structure:
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