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Target
Cyclin-dependent kinase 6/G1/S-specific cyclin-D1
Ligand
BDBM370256
Substrate
n/a
Meas. Tech.
CDK6/Cyclin D1 Mobility Shift Assay
Ki
0.190±n/a nM
Citation
 Freeman-Cook, KD; Hoffman, RL; Nagata, A; Ninkovic, S CDK2/4/6 inhibitors US Patent  US10233188 Publication Date 3/19/2019 
Target
Name:
Cyclin-dependent kinase 6/G1/S-specific cyclin-D1
Synonyms:
CDK6/Cyclin D1
Type:
Enzyme
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Cyclin-dependent kinase 6
Synonyms:
Cell division protein kinase 6 | Cyclin-dependent kinase 6 (CDK 6) | Serine/threonine-protein kinase PLSTIRE | CDK6_HUMAN | CDK6 | CDKN6
Type:
Enzyme Subunit
Mol. Mass.:
36937.42
Organism:
Human
Description:
Q00534
Residue:
326
Sequence:
MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA
  
Component 2
Name:
G1/S-specific cyclin-D1
Synonyms:
CCND1_MOUSE | Ccnd1 | Cyl-1 | Cyclin D1
Type:
Enzyme Subunit
Mol. Mass.:
33418.84
Organism:
Mouse
Description:
n/a
Residue:
295
Sequence:
MEHQLLCCEVETIRRAYPDTNLLNDRVLRAMLKTEETCAPSVSYFKCVQKEIVPSMRKIVATWMLEVCEEQKCEEEVFPLAMNYLDRFLSLEPLKKSRLQLLGATCMFVASKMKETIPLTAEKLCIYTDNSIRPEELLQMELLLVNKLKWNLAAMTPHDFIEHFLSKMPEADENKQTIRKHAQTFVALCATDVKFISNPPSMVAAGSVVAAMQGLNLGSPNNFLSCYRTTHFLSRVIKCDPDCLRACQEQIEALLESSLRQAQQNVDPKATEEEGEVEEEAGLACTPTDVRDVDI
  
Inhibitor
Name:
BDBM370256
Synonyms:
US10233188, Example 143 | BDBM467151
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
CS(=O)(=O)N1CCC(CC1)Nc1ncc2cc(CO)c(=O)n(C3CCCC3)c2n1
Structure:
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