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Target
D(1A) dopamine receptor
Ligand
BDBM372117
Substrate
n/a
Meas. Tech.
In Vitro Binding Assay for DDR1
IC50
17.7±n/a nM
Citation
 Buettelmann, B; Kocer, B; Kuhn, B; Prunotto, M; Richter, H; Ritter, M; Rudolph, M; Satz, AL Triaza-spirodecanones as DDR1 inhibitors US Patent  US10239876 Publication Date 3/26/2019 
Target
Name:
D(1A) dopamine receptor
Synonyms:
DA D1 receptor | DOPAMINE D1 | DRD1 | DRD1_HUMAN | Dopamine D1 receptor | Dopamine D1 receptor (D1R) | Dopamine D1A
Type:
Enzyme
Mol. Mass.:
49303.43
Organism:
Homo sapiens (Human)
Description:
P21728
Residue:
446
Sequence:
MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT
  
Inhibitor
Name:
BDBM372117
Synonyms:
(R)- or (S)-3-(2-Oxo-2-(2-(trifluoromethyl)morpholino)ethyl)-1-phenyl-8-(1H-pyrazolo[4,3-b]pyridine-5-carbonyl)-1,3,8-triazaspiro[4.5]decan-4-one | US10239876, Example 140 | US10435407, Example 140
Type:
Small organic molecule
Emp. Form.:
C27H28F3N7O4
Mol. Mass.:
571.5509
SMILES:
FC(F)(F)[C@H]1CN(CCO1)C(=O)CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2ccc3[nH]ncc3n2)C1=O |r|
Structure:
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