Reaction Details Report a problem with these data
Target
Interleukin-22 receptor subunit alpha-2
Ligand
BDBM261500
Substrate
n/a
Meas. Tech.
TH17 Cytokine Inhibition ELISA
IC50
<10000±n/a nM
Citation
 Gaweco, A; Tilley, JW; Walker, J; Palmer, S; Blinn, J ROR modulators and their uses US Patent  US9708268 Publication Date 7/18/2017 
Target
Name:
Interleukin-22 receptor subunit alpha-2
Synonyms:
IL-22 receptor subunit alpha-2 | il-22 | I22R2_HUMAN | IL-22R-alpha-2 | IL-22RA2 | IL22RA2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
30556.44
Organism:
Homo sapiens (Human)
Description:
Q969J5
Residue:
263
Sequence:
MMPKHCFLGFLISFFLTGVAGTQSTHESLKPQRVQFQSRNFHNILQWQPGRALTGNSSVYFVQYKIMFSCSMKSSHQKPSGCWQHISCNFPGCRTLAKYGQRQWKNKEDCWGTQELSCDLTSETSDIQEPYYGRVRAASAGSYSEWSMTPRFTPWWETKIDPPVMNITQVNGSLLVILHAPNLPYRYQKEKNVSIEDYYELLYRVFIINNSLEKEQKVYEGAHRAVEIEALTPHSSYCVVAEIYQPMLDRRSQRSEERCVEIP
  
Inhibitor
Name:
BDBM261500
Synonyms:
1-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzyl)-N-methyl-1,2,3,4-tetrahydroquinoline-6-carboxamide | US9708268, 3
Type:
Small organic molecule
Emp. Form.:
C21H19F6NO3
Mol. Mass.:
447.3709
SMILES:
OC(c1ccc(CN2CCCc3cc(COC=O)ccc23)cc1)(C(F)(F)F)C(F)(F)F
Structure:
Search PDB for entries with ligand similarity: