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Target
Oxysterols receptor LXR-beta
Ligand
BDBM372430
Substrate
n/a
Meas. Tech.
Gal4 LXRbeta Cotransfection Assay
EC50
<1000±n/a nM
Citation
 Mohan, R Liver X receptor (LXR) modulators US Patent  US10246419 Publication Date 4/2/2019 
Target
Name:
Oxysterols receptor LXR-beta
Synonyms:
LXRB | Liver X receptor beta (NR1H2) | Liver X, LXR beta | NER | NR1H2 | NR1H2_HUMAN | Nuclear receptor NER | UNR | Ubiquitously-expressed nuclear receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
50978.79
Organism:
Homo sapiens (Human)
Description:
P55055
Residue:
460
Sequence:
MSSPTTSSLDTPLPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDWVIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQESQSQSQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
  
Inhibitor
Name:
BDBM372430
Synonyms:
1-(cyclopropylmethyl)- 5-(3'-(methylsulfonyl)- [1,1'-biphenyl]-4-yl)- 3-(trifluoromethyl)- 1H-pyrazole | US10246419, Compound 18
Type:
Small organic molecule
Emp. Form.:
C21H19F3N2O2S
Mol. Mass.:
420.448
SMILES:
CS(=O)(=O)c1cccc(c1)-c1ccc(cc1)-c1cc(nn1CC1CC1)C(F)(F)F
Structure:
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