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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM374332
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
<100.0±n/a nM
Citation
 Chan, T; Guckian, K; Jenkins, T; Thomas, J; Vessels, J; Kumaravel, G; Meissner, R; Lyssikatos, J; Lucas, B; Leaf, I; Duffield, J IRAK4 inhibiting agents US Patent  US10246456 Publication Date 4/2/2019 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM374332
Synonyms:
(S)-4-amino-4-(6-(1-(6-(hydroxymethyl)pyridin-2-yl)-4-(2-methoxyethoxy)-1H-indazol-6-yl)pyridin-2-yl)butan-1-ol | US10246456, Example 484 | US10577367, Example 484
Type:
Small organic molecule
Emp. Form.:
C25H29N5O4
Mol. Mass.:
463.5289
SMILES:
COCCOc1cc(cc2n(ncc12)-c1cccc(CO)n1)-c1cccc(n1)[C@@H](N)CCCO
Structure:
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