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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM374216
Substrate
n/a
Meas. Tech.
Cell-Based Assay
EC50
<1000±n/a nM
Citation
 Chan, T; Guckian, K; Jenkins, T; Thomas, J; Vessels, J; Kumaravel, G; Meissner, R; Lyssikatos, J; Lucas, B; Leaf, I; Duffield, J IRAK4 inhibiting agents US Patent  US10246456 Publication Date 4/2/2019 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM374216
Synonyms:
(S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-4-(1-methyl-1H-pyrazol-3-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol | US10246456, Example 357
Type:
Small organic molecule
Emp. Form.:
C24H23N7O
Mol. Mass.:
425.4857
SMILES:
C[C@H](N)c1cccc(n1)-c1cc(-c2ccn(C)n2)c2cnn(-c3cccc(CO)n3)c2c1
Structure:
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