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Target
Protein Wnt-3a
Ligand
BDBM375009
Substrate
n/a
Meas. Tech.
Wnt-Luc Reporter Assay
IC50
0.100±n/a nM
Citation
 Cheng, D; Gao, W; Han, D; Pan, S; Zhang, G N-(hetero)aryl, 2-(hetero)aryl-substituted acetamides for use as Wnt signaling modulators US Patent  US10251893 Publication Date 4/9/2019 
Target
Name:
Protein Wnt-3a
Synonyms:
WNT3A | WNT3A_HUMAN
Type:
PROTEIN
Mol. Mass.:
39379.02
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1469237
Residue:
352
Sequence:
MAPLGYFLLLCSLKQALGSYPIWWSLAVGPQYSSLGSQPILCASIPGLVPKQLRFCRNYVEIMPSVAEGIKIGIQECQHQFRGRRWNCTTVHDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTAAICGCSSRHQGSPGKGWKWGGCSEDIEFGGMVSREFADARENRPDARSAMNRHNNEAGRQAIASHMHLKCKCHGLSGSCEVKTCWWSQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRPRYTYFKVPTERDLVYYEASPNFCEPNPETGSFGTRDRTCNVSSHGIDGCDLLCCGRGHNARAERRREKCRCVFHWCCYVSCQECTRVYDVHTCK
  
Inhibitor
Name:
BDBM375009
Synonyms:
2-(2',3-difluoro-2,4'-bipyridin-5-yl)-N-(5-(pyrazin-2-yl)pyridin-2-yl)acetamide | US10251893, Cpd 205
Type:
Small organic molecule
Emp. Form.:
C21H14F2N6O
Mol. Mass.:
404.3723
SMILES:
Fc1cc(ccn1)-c1ncc(CC(=O)Nc2ccc(cn2)-c2cnccn2)cc1F
Structure:
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