Reaction Details Report a problem with these data
Target
Free fatty acid receptor 1
Ligand
BDBM374855
Substrate
n/a
Meas. Tech.
IPOne assay
EC50
7.00±n/a nM
Citation
 Eckhardt, M; Wagner, H; Peters, S Indanylaminopyrazinylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof US Patent  US10253004 Publication Date 4/9/2019 
Target
Name:
Free fatty acid receptor 1
Synonyms:
FFAR1 | FFAR1_HUMAN | G-protein Coupled Receptor 40 | GPR40
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
31473.32
Organism:
Homo sapiens (Human)
Description:
O14842
Residue:
300
Sequence:
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
  
Inhibitor
Name:
BDBM374855
Synonyms:
US10253004, Example 1 | trans-2-(5-{(R)-7-Fluoro-4-[4-(3-hydroxy-3-methyl-butoxy)-2,6-dimethyl-phenyl]-indan-1-ylamino}-pyrazin-2-yl)-cyclopropanecarboxylic acid (ca. 1:1 mixture of trans-diastereomers with respect to cyclopropane)
Type:
Small organic molecule
Emp. Form.:
C30H34FN3O4
Mol. Mass.:
519.6071
SMILES:
Cc1cc(OCCC(C)(C)O)cc(C)c1-c1ccc(F)c2[C@@H](CCc12)Nc1cnc(cn1)C1C[C@@H]1C(O)=O |r,wU:21.27,wD:34.39,(-1.75,1.34,;-3.26,1.01,;-4.29,2.16,;-5.79,1.84,;-6.82,2.98,;-8.33,2.66,;-9.36,3.81,;-10.87,3.49,;-11.9,4.63,;-11.34,2.02,;-10.87,5.03,;-6.27,.37,;-5.24,-.77,;-5.71,-2.23,;-3.73,-.45,;-2.7,-1.59,;-3.18,-3.06,;-2.15,-4.2,;-.64,-3.88,;.39,-5.03,;-.16,-2.42,;1.24,-1.79,;1.08,-.26,;-.42,.06,;-1.2,-1.27,;2.56,-2.56,;3.89,-1.79,;3.89,-.25,;5.23,.52,;6.56,-.25,;6.56,-1.79,;5.23,-2.56,;7.9,.52,;9.23,1.29,;9.23,-.25,;10.56,.52,;11.9,-.25,;10.56,2.06,)|
Structure:
Search PDB for entries with ligand similarity: