Reaction Details Report a problem with these data
Target
Homoisocitrate dehydrogenase
Ligand
BDBM23217
Substrate
BDBM23214
Meas. Tech.
Enzyme Inhibition Assay
pH
7.8±n/a
Temperature
301.15±n/a K
Ki
5200000±n/a nM
Km
211000±n/a nM
kcat
46±n/a 1/sec
Citation
 Yamamoto, T; Miyazaki, K; Eguchi, T Substrate specificity analysis and inhibitor design of homoisocitrate dehydrogenase. Bioorg Med Chem 15:1346-55 (2007) [PubMed]  Article 
Target
Name:
Homoisocitrate dehydrogenase
Synonyms:
DraHICDH | Homoisocitrate Dehydrogenase (HICDH) | Isocitrate dehydrogenase
Type:
Enzyme
Mol. Mass.:
35741.95
Organism:
Deinococcus radiodurans
Description:
Q76G12
Residue:
332
Sequence:
MAKYRICLIEGDGIGHEVIPAAKRVLEAAGFDAEYVHAEAGYEYFLDHGTSVPEATYDAVENTDATLFGAATSPSGEKPAGFFGAIRHLRQKYNLYANVRPTKTRPVPHSYENVDLVIVRENTQGLYVEQERRYGDTAIADTVITREASDRIGKFAADLAMKRSKRLTVVHKSNVLPVTQGLFMNTILDHTKTVEGLSTSTMIVDNAAMQLVRNPQQFDVMVMTNMFGDILSDLAAGLVGGLGIAASGNVGDQFGIFESVHGSAPDIAGQGISNPTATILAAVIMLDHLGDHETARRLDNAINKVLAEPRTRDLGGTAGTQEFTEAVIKALA
  
Inhibitor
Name:
BDBM23217
Synonyms:
(2R,3E)-2-hydroxy-3-(3-hydroxypropylidene)butanedioic acid | 3-Hydroxypropylidenemalate, 27a
Type:
Small organic molecule
Emp. Form.:
C7H10O6
Mol. Mass.:
190.1507
SMILES:
[H][C@](O)(C(O)=O)C(=C/CCO)\C(O)=O |r|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM23214
Synonyms:
(-)-homoisocitric acid | (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylic acid | (2R,3S)-Homoisocitrate | Homoisocitrate
Type:
Small organic molecule
Emp. Form.:
C7H10O7
Mol. Mass.:
206.1501
SMILES:
[H][C@](O)(C(O)=O)[C@]([H])(CCC(O)=O)C(O)=O |r|
Structure:
Search PDB for entries with ligand similarity: