Reaction Details Report a problem with these data
Target
Ubiquitin carboxyl-terminal hydrolase isozyme L3
Ligand
BDBM23426
Substrate
BDBM23422
Meas. Tech.
Enzyme Inhibition Assay
pH
7.8±n/a
Temperature
295.15±n/a K
IC50
154000±n/a nM
Km
83.3±1.5 nM
Citation
Hirayama, K; Aoki, S; Nishikawa, K; Matsumoto, T; Wada, K Identification of novel chemical inhibitors for ubiquitin C-terminal hydrolase-L3 by virtual screening. Bioorg Med Chem 15:6810-8 (2007) [PubMed] Article
Target
Name:
Ubiquitin carboxyl-terminal hydrolase isozyme L3
Synonyms:
UCHL3 | UCHL3_HUMAN | Ubiquitin C-terminal Hydrolase L3 (UCH-L3) | Ubiquitin thioesterase L3
Type:
Hydrolase; protease
Mol. Mass.:
26168.69
Organism:
Homo sapiens (Human)
Description:
Human recombinant UCH-L3 was purchased from Boston Biochem, Inc.(Cambridge, MA).
Residue:
230
Sequence:
MEGQRWLPLEANPEVTNQFLKQLGLHPNWQFVDVYGMDPELLSMVPRPVCAVLLLFPITEKYEVFRTEEEEKIKSQGQDVTSSVYFMKQTISNACGTIGLIHAIANNKDKMHFESGSTLKKFLEESVSMSPEERARYLENYDAIRVTHETSAHEGQTEAPSIDEKVDLHFIALVHVDGHLYELDGRKPFPINHGETSDETLLEDAIEVCKKFMERDPDELRFNAIALSAA
Inhibitor
Name:
BDBM23426
Synonyms:
3-hydroxy-5-(4-methoxyphenyl)-1-(1,3,4-thiadiazol-2-yl)-4-(thiophen-2-ylcarbonyl)-2,5-dihydro-1H-pyrrol-2-one | ChemBridge CNS-Set 6237842, 6 | cid_2891549
Type:
Small organic molecule
Emp. Form.:
C18H13N3O4S2
Mol. Mass.:
399.444
SMILES:
COc1ccc(cc1)C1C(C(=O)c2cccs2)C(=O)C(=O)N1c1nncs1