Target

Ligand

Substrate

Meas. Tech.

Enzyme Inhibition Assay

pH

7.8±n/a

Temperature

295.15±n/a K

Citation

 Hirayama, K; Aoki, S; Nishikawa, K; Matsumoto, T; Wada, K Identification of novel chemical inhibitors for ubiquitin C-terminal hydrolase-L3 by virtual screening. Bioorg Med Chem 15:6810-8 (2007) [PubMed]  Article Copy BDB DOI

More Info.:

Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method

Name:

Ubiquitin carboxyl-terminal hydrolase isozyme L3

Synonyms:

UCHL3 | UCHL3_HUMAN | Ubiquitin C-terminal Hydrolase L3 (UCH-L3) | Ubiquitin thioesterase L3

Type:

Hydrolase; protease

Mol. Mass.:

26168.69

Organism:

Homo sapiens (Human)

Description:

Human recombinant UCH-L3 was purchased from Boston Biochem, Inc.(Cambridge, MA).

Residue:

230

Sequence:

MEGQRWLPLEANPEVTNQFLKQLGLHPNWQFVDVYGMDPELLSMVPRPVCAVLLLFPITEKYEVFRTEEEEKIKSQGQDVTSSVYFMKQTISNACGTIGLIHAIANNKDKMHFESGSTLKKFLEESVSMSPEERARYLENYDAIRVTHETSAHEGQTEAPSIDEKVDLHFIALVHVDGHLYELDGRKPFPINHGETSDETLLEDAIEVCKKFMERDPDELRFNAIALSAA

Blast this sequence in BindingDB or PDB

  
Blast E-value cutoff:

Name:

BDBM23428

Synonyms:

ChemBridge CNS-Set 6699002, 8 | N-cyclopropyl-2-[(4-methoxybenzene)(4-methylphenyl)sulfonamido]acetamide

Type:

Small organic molecule

Emp. Form.:

C19H22N2O4S

Mol. Mass.:

374.454

SMILES:

COc1ccc(cc1)S(=O)(=O)N(CC(=O)NC1CC1)c1ccc(C)cc1

Structure:

Search PDB for entries with ligand similarity:

Similarity to this molecule at least:

Name:

BDBM23422

Synonyms:

Ub-AMC | ubiquitin-7-amido-4-methylcoumarin

Type:

Fluorogenic substrate

Emp. Form.:

n/a

Mol. Mass.:

n/a

SMILES:

n/a

Structure: