Reaction Details Report a problem with these data
Target
Ubiquitin carboxyl-terminal hydrolase isozyme L3
Ligand
BDBM23429
Substrate
BDBM23422
Meas. Tech.
Enzyme Inhibition Assay
pH
7.8±n/a
Temperature
295.15±n/a K
IC50
>386000±n/a nM
Km
83.3±1.5 nM
Citation
Hirayama, K; Aoki, S; Nishikawa, K; Matsumoto, T; Wada, K Identification of novel chemical inhibitors for ubiquitin C-terminal hydrolase-L3 by virtual screening. Bioorg Med Chem 15:6810-8 (2007) [PubMed] Article
Target
Name:
Ubiquitin carboxyl-terminal hydrolase isozyme L3
Synonyms:
UCHL3 | UCHL3_HUMAN | Ubiquitin C-terminal Hydrolase L3 (UCH-L3) | Ubiquitin thioesterase L3
Type:
Hydrolase; protease
Mol. Mass.:
26168.69
Organism:
Homo sapiens (Human)
Description:
Human recombinant UCH-L3 was purchased from Boston Biochem, Inc.(Cambridge, MA).
Residue:
230
Sequence:
MEGQRWLPLEANPEVTNQFLKQLGLHPNWQFVDVYGMDPELLSMVPRPVCAVLLLFPITEKYEVFRTEEEEKIKSQGQDVTSSVYFMKQTISNACGTIGLIHAIANNKDKMHFESGSTLKKFLEESVSMSPEERARYLENYDAIRVTHETSAHEGQTEAPSIDEKVDLHFIALVHVDGHLYELDGRKPFPINHGETSDETLLEDAIEVCKKFMERDPDELRFNAIALSAA
Inhibitor
Name:
BDBM23429
Synonyms:
2-[benzene(3-methoxyphenyl)sulfonamido]-N-cyclopentylacetamide | ChemBridge CNS-Set 6187162, 9
Type:
Small organic molecule
Emp. Form.:
C20H24N2O4S
Mol. Mass.:
388.481
SMILES:
COc1cccc(c1)N(CC(=O)NC1CCCC1)S(=O)(=O)c1ccccc1