Reaction Details Report a problem with these data
Target
Neutrophil elastase
Ligand
BDBM23700
Substrate
BDBM23699
Meas. Tech.
Human Neutrophil Elastase Inhibition Assay
pH
7.5±n/a
Temperature
298.15±n/a K
Ki
15±n/a nM
Citation
Schepetkin, IA; Khlebnikov, AI; Quinn, MT N-benzoylpyrazoles are novel small-molecule inhibitors of human neutrophil elastase. J Med Chem 50:4928-38 (2007) [PubMed] Article
Target
Name:
Neutrophil elastase
Synonyms:
Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:
Enzyme
Mol. Mass.:
28532.38
Organism:
Homo sapiens (Human)
Description:
P08246
Residue:
267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
Inhibitor
Name:
BDBM23700
Synonyms:
N-Benzoylpyrazole deriv., 2 | methyl 1-[(4-chlorophenyl)carbonyl]-1H-pyrazole-5-carboxylate
Type:
Small organic molecule
Emp. Form.:
C12H9ClN2O3
Mol. Mass.:
264.664
SMILES:
COC(=O)c1ccnn1C(=O)c1ccc(Cl)cc1