Reaction Details Report a problem with these data
Target
Chymotrypsin-C
Ligand
BDBM23703
Substrate
BDBM23729
Meas. Tech.
Human Neutrophil Elastase Inhibition Assay
IC50
2700±n/a nM
Citation
 Schepetkin, IA; Khlebnikov, AI; Quinn, MT N-benzoylpyrazoles are novel small-molecule inhibitors of human neutrophil elastase. J Med Chem 50:4928-38 (2007) [PubMed]  Article 
Target
Name:
Chymotrypsin-C
Synonyms:
CLCR | CTRC | CTRC_HUMAN | Caldecrin | Chymotrypsin | Chymotrypsin C | Chymotrypsin-C
Type:
Enzyme
Mol. Mass.:
29487.98
Organism:
Homo sapiens (Human)
Description:
Q99895
Residue:
268
Sequence:
MLGITVLAALLACASSCGVPSFPPNLSARVVGGEDARPHSWPWQISLQYLKNDTWRHTCGGTLIASNFVLTAAHCISNTRTYRVAVGKNNLEVEDEEGSLFVGVDTIHVHKRWNALLLRNDIALIKLAEHVELSDTIQVACLPEKDSLLPKDYPCYVTGWGRLWTNGPIADKLQQGLQPVVDHATCSRIDWWGFRVKKTMVCAGGDGVISACNGDSGGPLNCQLENGSWEVFGIVSFGSRRGCNTRKKPVVYTRVSAYIDWINEKMQL
  
Inhibitor
Name:
BDBM23703
Synonyms:
1-benzoyl-4-nitro-1H-pyrazole | N-Benzoylpyrazole deriv., 5
Type:
Small organic molecule
Emp. Form.:
C10H7N3O3
Mol. Mass.:
217.1809
SMILES:
[O-][N+](=O)c1cnn(c1)C(=O)c1ccccc1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM23729
Synonyms:
Suc-Ala-Ala-Pro-Phe-7-amino-4-methylcoumarin
Type:
n/a
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
n/a
Structure: