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Target
Chymotrypsin-C
Ligand
BDBM23721
Substrate
BDBM23729
Meas. Tech.
Human Neutrophil Elastase Inhibition Assay
IC50
3500±n/a nM
Citation
Schepetkin, IA; Khlebnikov, AI; Quinn, MT N-benzoylpyrazoles are novel small-molecule inhibitors of human neutrophil elastase. J Med Chem 50:4928-38 (2007) [PubMed] Article
More Info.:
Target
Name:
Chymotrypsin-C
Synonyms:
CLCR | CTRC | CTRC_HUMAN | Caldecrin | Chymotrypsin | Chymotrypsin C | Chymotrypsin-C
Type:
Enzyme
Mol. Mass.:
29487.98
Organism:
Homo sapiens (Human)
Description:
Q99895
Residue:
268
Sequence:
MLGITVLAALLACASSCGVPSFPPNLSARVVGGEDARPHSWPWQISLQYLKNDTWRHTCGGTLIASNFVLTAAHCISNTRTYRVAVGKNNLEVEDEEGSLFVGVDTIHVHKRWNALLLRNDIALIKLAEHVELSDTIQVACLPEKDSLLPKDYPCYVTGWGRLWTNGPIADKLQQGLQPVVDHATCSRIDWWGFRVKKTMVCAGGDGVISACNGDSGGPLNCQLENGSWEVFGIVSFGSRRGCNTRKKPVVYTRVSAYIDWINEKMQL
Inhibitor
Name:
BDBM23721
Synonyms:
4-chloro-1-[(2-fluorophenyl)carbonyl]-3,5-dimethyl-1H-pyrazole | N-Benzoylpyrazole deriv., 29
Type:
Small organic molecule
Emp. Form.:
C12H10ClFN2O
Mol. Mass.:
252.672
SMILES:
Cc1nn(C(=O)c2ccccc2F)c(C)c1Cl