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Target
fMet-Leu-Phe receptor
Ligand
BDBM377269
Substrate
n/a
Meas. Tech.
Measuring Agonistic Activity of Compounds in hFPR1-Gα15-CHO and hFPR2-Aq-CHO Cell
EC50
<1±n/a nM
Citation
 Jakob, F; Nordhoff, S; Rider, D; Wagener, M; Bahrenberg, G; Dunkern, T 6-membered cyclic amines or lactames substituted with urea and phenyl US Patent  US10265310 Publication Date 4/23/2019 
Target
Name:
fMet-Leu-Phe receptor
Synonyms:
FPR | FPR1 | FPR1_HUMAN | Formyl peptide Receptor | N-formyl peptide receptor 1 | N-formylpeptide chemoattractant receptor | fMLP receptor | fMet-Leu-Phe receptor | formyl peptide receptor 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
38456.14
Organism:
Homo sapiens (Human)
Description:
gi_4503779
Residue:
350
Sequence:
METNSSLPTNISGGTPAVSAGYLFLDIITYLVFAVTFVLGVLGNGLVIWVAGFRMTHTVTTISYLNLAVADFCFTSTLPFFMVRKAMGGHWPFGWFLCKFVFTIVDINLFGSVFLIALIALDRCVCVLHPVWTQNHRTVSLAKKVIIGPWVMALLLTLPVIIRVTTVPGKTGTVACTFNFSPWTNDPKERINVAVAMLTVRGIIRFIIGFSAPMSIVAVSYGLIATKIHKQGLIKSSRPLRVLSFVAAAFFLCWSPYQVVALIATVRIRELLQGMYKEIGIAVDVTSALAFFNSCLNPMLYVFMGQDFRERLIHALPASLERALTEDSTQTSDTATNSTLPSAEVELQAK
  
Inhibitor
Name:
BDBM377269
Synonyms:
US10265310, Example 15 | rac-trans-1-(4-chlorophenyl)-3-(4-(4-methoxyphenyl)-1-(3-methoxypropanoyl)piperidin-3-yl)urea
Type:
Small organic molecule
Emp. Form.:
C23H28ClN3O4
Mol. Mass.:
445.939
SMILES:
COCCC(=O)N1CC[C@@H]([C@H](C1)NC(=O)Nc1ccc(Cl)cc1)c1ccc(OC)cc1 |r|
Structure:
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