Reaction Details Report a problem with these data
Target
Solute carrier family 22 member 12
Ligand
BDBM377694
Substrate
n/a
Meas. Tech.
URAT1 (Urate Anion Transporter) Inhibition Activity Assay
IC50
234±n/a nM
Citation
 Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y Carboxy substituted (hetero) aromatic ring derivatives and preparation method and uses thereof US Patent  US10266496 Publication Date 4/23/2019 
Target
Name:
Solute carrier family 22 member 12
Synonyms:
OATL4 | Organic anion transporter 4-like protein | RST | Renal-specific transporter | S22AC_HUMAN | SLC22A12 | Solute carrier family 22 member 12 | Solute carrier family 22 member 12 (URAT1) | URAT1 | Urate anion exchanger 1 | Urate anion exchanger 1 (URAT1) | Uric Acid Transporter 1 (URAT1)
Type:
Enzyme
Mol. Mass.:
59638.65
Organism:
Homo sapiens (Human)
Description:
Q96S37
Residue:
553
Sequence:
MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGWVYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSYLQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLGFSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAFGFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCILANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGAILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQAVKKATHGTLGNSVLKSTQF
  
Inhibitor
Name:
BDBM377694
Synonyms:
US10266496, Example 6
Type:
Small organic molecule
Emp. Form.:
C18H11F3N2O3
Mol. Mass.:
360.2867
SMILES:
Cn1c(cc2c(cc(cc12)C#N)-c1ccc(C(O)=O)c(O)c1)C(F)(F)F
Structure:
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